Taysi Seyithan, Akcay Fatih, Uslu Celil, Dogru Yusuf, Gulcin Ilhami
Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey.
Biol Trace Elem Res. 2003 Jan;91(1):11-8. doi: 10.1385/BTER:91:1:11.
In this study, we investigated the levels of serum Zn, Cu, Mg, Mn, Fe, ceruloplasmin (Cp), transferrin (Trf), and albumin in laryngeal carcinoma and correlated their levels with the cancer stage. The sera from 35 patients with laryngeal cancer (10 at stage II, 12 at stage III, and 13 at stage IV) were extracted before treatment and compared with those from the healthy control group (n=15). Although serum Fe and Mn concentrations were lower in the laryngeal cancer groups (for all stages) than in the control group, the difference was not statistically significant (p>0.05). The higher Cu (p<0.001) and Cp (p<0.01) and lower Zn (p<0.01), Mg (p<0.001), and Trf (p<0.01) concentrations were found in laryngeal cancer groups (for each stage) when compared to the control group. In the comparison of stages II, III, and IV (with each other), all parameters were found to be statistically not significant (p>0.05). On the other hand, no meaningful difference was found in terms of the serum albumin level. In our opinion, alterations in the level of trace elements and antioxidant proteins, important for many metabolic processes, in laryngeal cancer may not be a reason for but is, in fact, a consequence of the disease itself.
在本研究中，我们调查了喉癌患者血清中锌（Zn）、铜（Cu）、镁（Mg）、锰（Mn）、铁（Fe）、铜蓝蛋白（Cp）、转铁蛋白（Trf）和白蛋白的水平，并将其水平与癌症分期相关联。在治疗前采集了35例喉癌患者（II期10例、III期12例、IV期13例）的血清，并与健康对照组（n = 15）的血清进行比较。尽管喉癌组（各期）血清铁和锰浓度低于对照组，但差异无统计学意义（p>0.05）。与对照组相比，喉癌组（各期）的铜（p<0.001）和铜蓝蛋白（p<0.01）浓度较高，而锌（p<0.01）、镁（p<0.001）和转铁蛋白（p<0.01）浓度较低。在II期、III期和IV期（相互比较）中，所有参数差异均无统计学意义（p>0.05）。另一方面，血清白蛋白水平未发现有意义的差异。我们认为，喉癌中对许多代谢过程至关重要的微量元素和抗氧化蛋白水平的改变可能不是疾病的原因，而实际上是疾病本身的结果。
