Carter J
J Reprod Fertil. 1976 Jan;46(1):211-6. doi: 10.1530/jrf.0.0460211.
During pregnancy in mice, cell-mediated immunity as measured by a contact allergic reaction to picryl chloride was diminished (P less than 0.001). Mice in which delay of implantation was maintained by progesterone, and mice with progesterone- and oestradiol-maintained pregnancies, also showed a reduction in the inflammatory response. The response of pseudopregnant mice did not differ from that of the non-pregnant controls. Young mice sensitized before complete immunological competence gave a 50% response. The response doubled in animals given a second sensitization. The extent of the response in females with delay of implantation varied inversely with the dose of progesterone. A range of oestrogen doses gave the same depression in the response when given to pseudopregnant animals. Administration of HCG to pseudopregnant mice also reduced the inflammatory response.
在小鼠怀孕期间，通过对氯化苦基的接触性过敏反应所测定的细胞介导免疫功能减弱（P小于0.001）。用孕酮维持着床延迟的小鼠，以及用孕酮和雌二醇维持妊娠的小鼠，其炎症反应也有所降低。假孕小鼠的反应与未孕对照小鼠没有差异。在完全具备免疫能力之前致敏的幼鼠有50%的反应。给予第二次致敏的动物反应加倍。着床延迟的雌性动物的反应程度与孕酮剂量呈反比。给予假孕动物一系列雌激素剂量时，反应出现相同程度的降低。给假孕小鼠注射人绒毛膜促性腺激素也会降低炎症反应。
