Fabris N, Piantanelli L, Muzzioli M
Clin Exp Immunol. 1977 May;28(2):306-14.
The reactivity of spleen lymphocytes in a mixed lymphocyte culture and the in vivo PFC response to sheep erythrocytes have been evaluated in pregnant female mice and data compared with those observed in virgin sexually mature female mice daily treated either with progesterone or human chorionic gonadotropin (HCG) or human prolactin. The mixed lymphocyte reactivity is depressed at mid-pregnancy, whereas PFC response is increased. Comparable immunological modifications have been found in mice treated with HCG, but not in animals treated with progesterone or prolactin. The similarity between HCG treatment and pregnancy suggests that the rate of gonadotropin release may be one of the earliest events responsible for the immunological disturbances present during pregnancy, although its action on the lymphoid system seems to require the presence of the ovary. From these data and from the observation that HCG increases the PFC response also in thymusless nude female mice, it can be deduced that it acts on both T and B cells.
在怀孕的雌性小鼠中评估了混合淋巴细胞培养中脾淋巴细胞的反应性以及对绵羊红细胞的体内PFC反应，并将数据与每天用孕酮、人绒毛膜促性腺激素（HCG）或人催乳素处理的未孕性成熟雌性小鼠中观察到的数据进行比较。混合淋巴细胞反应性在妊娠中期降低，而PFC反应增加。在用HCG处理的小鼠中发现了类似的免疫改变，但在用孕酮或催乳素处理的动物中未发现。HCG处理与妊娠之间的相似性表明，促性腺激素释放速率可能是妊娠期间出现免疫紊乱的最早事件之一，尽管其对淋巴系统的作用似乎需要卵巢的存在。根据这些数据以及HCG也能增加无胸腺裸鼠雌性小鼠的PFC反应这一观察结果，可以推断它对T细胞和B细胞都有作用。
