Rota Paul A, Bellini William J
Measles Virus Section, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
J Infect Dis. 2003 May 15;187 Suppl 1:S270-6. doi: 10.1086/368042.
Molecular characterization of measles viruses is an important component of measles surveillance because these studies enhance our ability to identify the source and transmission pathways of the virus. Molecular surveillance is most beneficial when it is possible to observe the change in virus genotypes over time in a particular region. Such information can help to document the interruption of transmission of measles virus and thus provide an important method for assessing the effectiveness of vaccination programs. It is recommended that virus surveillance be conducted during all phases of measles control and be expanded to give an accurate description of the global distribution of measles genotypes. This review provides updated information on the circulation patterns of measles genotypes and examples of the utility of virologic surveillance.
麻疹病毒的分子特征分析是麻疹监测的重要组成部分，因为这些研究有助于我们识别病毒的来源和传播途径。当能够观察特定区域内病毒基因型随时间的变化时，分子监测最为有益。此类信息有助于记录麻疹病毒传播的中断情况，从而提供一种评估疫苗接种计划有效性的重要方法。建议在麻疹控制的各个阶段都开展病毒监测，并加以扩展，以准确描述麻疹基因型的全球分布情况。本综述提供了关于麻疹基因型传播模式的最新信息以及病毒学监测应用的实例。
