Zhan N, Wang S, Wang X
Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China.
Wei Sheng Yan Jiu. 2000 Jan 30;29(1):4-6.
The effects of phoxim at various dosage levels on sperm production and motility in rats were studied. Sperm motility was measured by computer assisted sperm analysis (CASA). The results showed that rats exposed to phoxim at higher doses(24.5 and 73.5 mg/kgBW) for 60 successive days showed significant reduction of daily sperm production as compared with the control (P < 0.05, P < 0.01). Sperm motion parameters such as currilinear velocity (VCL), straight line velocity(VSL), beat cross frequency(BCF), linearity(LIN) and straightness(STR) were significantly decreased than those of the control(P < 0.05, P < 0.01) which indicated a dose-dependent relationship to some extent. However, there was no obvious change in body weight, testis weight and the rate of motile sperm in epididymis. It suggests that the male reproductive toxicilIty of phoxim at higher doses (24.5 and 73.5 mg/kgBW) mainly induces a reduction of sperm production and motility.
研究了不同剂量水平的辛硫磷对大鼠精子生成和活力的影响。采用计算机辅助精子分析（CASA）测定精子活力。结果显示，连续60天暴露于高剂量（24.5和73.5mg/kg体重）辛硫磷的大鼠，与对照组相比，每日精子生成量显著降低（P<0.05，P<0.01）。精子运动参数如曲线速度（VCL）、直线速度（VSL）、鞭打交叉频率（BCF）、线性度（LIN）和直线性（STR）均显著低于对照组（P<0.05，P<0.01），这在一定程度上表明存在剂量依赖关系。然而，体重、睾丸重量和附睾中活动精子的比例没有明显变化。这表明高剂量（24.5和73.5mg/kg体重）辛硫磷对雄性生殖的毒性主要导致精子生成和活力降低。
