Hodges S, Lobo-Yeo A, Donaldson P, Tanner M S, Vergani D
Department of Child Health, Leicester Royal Infirmary.
Gut. 1991 Mar;32(3):299-302. doi: 10.1136/gut.32.3.299.
A positive family history of autoimmune disease is common among patients with autoimmune chronic active hepatitis, but usually autoimmunity is directed at organs other than the liver. We document for the first time the multiple occurrence of autoimmune chronic active hepatitis in a family. Out of a sibship of seven, three sisters developed this, one sister developed coeliac and autoimmune thyroid disease, one sister showed serological signs of autoimmunity, while the two brothers were well with no signs of autoimmunity. HLA typing showed that in association with the female sex DR3 seems to be more important than B8 in conferring susceptibility to autoimmune chronic active hepatitis, at least in this family.
自身免疫性慢性活动性肝炎患者中，自身免疫性疾病的家族史很常见，但通常自身免疫作用于肝脏以外的器官。我们首次记录了一个家族中多次出现自身免疫性慢性活动性肝炎的情况。在一个七口之家的兄弟姐妹中，有三个姐妹患了这种病，一个姐妹同时患了乳糜泻和自身免疫性甲状腺疾病，一个姐妹有自身免疫的血清学迹象，而两个兄弟身体健康，没有自身免疫的迹象。HLA分型显示，至少在这个家族中，与女性性别相关的DR3在赋予自身免疫性慢性活动性肝炎易感性方面似乎比B8更重要。
