Min Kweonsik, Munarriz Ricardo, Kim Noel N, Choi Seong, O'Connell Luke, Goldstein Irwin, Traish Abdulmaged M
Department of Urology, Inje University School of Medicine, Pusan, South Korea.
J Sex Marital Ther. 2003;29 Suppl 1:77-84. doi: 10.1080/713847131.
The goal of this study was to investigate the effects of ovariectomy and estrogen replacement on vaginal tissue integrity and vaginal lubrication in basal conditions and in response to pelvic nerve stimulation (PNS). Two weeks after ovariectomy, female New Zealand White rabbits were administered vehicle or estradiol (200 micrograms/day) for an additional 2 weeks. Ovariectomy caused significant vaginal atrophy and diminished vaginal lubrication in the basal state and after PNS, compared to intact controls. Estrogen replacement normalized lubrication values and tissue wet weight to control levels. In conclusion, vaginal tissue integrity and lubrication are diminished by ovariectomy and are normalized by estrogen replacement.
本研究的目的是调查卵巢切除术和雌激素替代对基础状态下以及对盆腔神经刺激（PNS）反应时阴道组织完整性和阴道润滑的影响。卵巢切除术后两周，给雌性新西兰白兔额外给药2周，给药方式为赋形剂或雌二醇（200微克/天）。与完整对照组相比，卵巢切除术导致基础状态下和PNS后阴道显著萎缩且阴道润滑减少。雌激素替代使润滑值和组织湿重恢复到对照水平。总之，卵巢切除术会降低阴道组织完整性和润滑，而雌激素替代可使其恢复正常。
