Yu Qianli, Larson Douglas F, Watson Ronald R
Department of Health Promotion Sciences, College of Public Health, University of Arizona Health Science Center, P.O. Box 245155, Tucson 85724, USA.
Life Sci. 2003 May 30;73(2):129-40. doi: 10.1016/s0024-3205(03)00260-1.
Methamphetamine (MA) not only affects the nervous system but also has cardiac toxicity and immunosuppressive properties. This manuscript will provide support that there is a relationship between MA use and heart disease as well as immune dysfunction. The cardiovascular manifestations of acute MA use include tachycardia, atrioventricular arrhythmias, myocardial ischemia, myocardial ischemia and hypertension, resulting in cardiac lesions. Chronic use of MA causes cardiomyopathy including cellular infiltration, myocardial hypertrophy, myocardium rupture and fibrosis. The increased catecholamine levels are responsible for the cardiac lesions induced by MA. The additional problem with MA use is its potential to disrupt the immune system function leading to suppression of mitogen-stimulated lymphocyte, a reduction in circulating lymphocyte numbers and alternation T-lymphocyte cytokine secretion as well as B cell proinflammatory cytokine secretion. Concomitant MA use and Human Immunodeficiency Virus (HIV) infection not only enhances immunosuppression associated with HIV but also increases the heart disease occurrence with a coincidentally complication of AIDS or AIDS medications.
甲基苯丙胺（MA）不仅会影响神经系统，还具有心脏毒性和免疫抑制特性。本手稿将提供证据支持MA使用与心脏病以及免疫功能障碍之间存在关联。急性使用MA的心血管表现包括心动过速、房室心律失常、心肌缺血、心肌梗死和高血压，进而导致心脏病变。长期使用MA会引发心肌病，包括细胞浸润、心肌肥大、心肌破裂和纤维化。儿茶酚胺水平升高是MA所致心脏病变的原因。使用MA的另一个问题是其有可能破坏免疫系统功能，导致丝裂原刺激的淋巴细胞受到抑制、循环淋巴细胞数量减少、T淋巴细胞细胞因子分泌改变以及B细胞促炎细胞因子分泌改变。同时使用MA和感染人类免疫缺陷病毒（HIV）不仅会增强与HIV相关的免疫抑制，还会增加心脏病的发生率，同时伴有艾滋病或艾滋病药物的并发症。
