Iwalewa E O, Iwalewa O J, Adeboye J O
Department of Pharmacology, Obafemi Awolowo University, Ile-Ife, Nigeria.
J Ethnopharmacol. 2003 Jun;86(2-3):229-34. doi: 10.1016/s0378-8741(03)00081-3.
The chloroform, methanolic and ether extracts of Vernonia cinerea (Asteraceae; Less) leaf (100, 200 and 400mg/kg intraperitoneally) were tested in: acetic acid-induced writhing in mice, carrageenin-induced oedema and brewer's yeast-induced pyrexia in rats to assess their analgesic, anti-inflammatory, antipyretic and behavioral activities, respectively. The changes in writhings and behavioural activities in mice, the pyrexia and paw volumes in rats were reduced significantly (P<0.05) compared to the control. There was an increase in pain threshold on the oedematous right hind limb paw of the rats. These results indicate that the extracts could possess analgesic, antipyretic and anti-inflammatory properties. All these effects and the changes in the behavioural activities could be suggested as contributory effects to the use of V. cinerea leaf in the treatment of malaria.
对灰叶斑鸠菊（菊科；Less）叶的氯仿提取物、甲醇提取物和乙醚提取物（腹腔注射，剂量分别为100、200和400mg/kg）进行了以下实验：分别在小鼠醋酸诱导扭体实验、大鼠角叉菜胶诱导水肿实验和啤酒酵母诱导发热实验中评估其镇痛、抗炎、解热及行为学活性。与对照组相比，小鼠扭体次数和行为学活性的变化、大鼠的发热情况和爪体积均显著降低（P<0.05）。大鼠水肿右后肢爪的痛阈升高。这些结果表明，提取物可能具有镇痛、解热和抗炎特性。所有这些作用以及行为学活性的变化都可能是灰叶斑鸠菊叶用于治疗疟疾的辅助作用。
