Goldberg Michel, Six Ngampis, Decup Frank, Lasfargues Jean-Jacques, Salih Erdjan, Tompkins Kevin, Veis Arthur
Faculté de Chirurgie Dentaire, Université Paris V, Montrouge, France.
Am J Dent. 2003 Feb;16(1):66-76.
Direct capping of bioactive molecules or implantation of these molecules in the pulp may induce the formation of reparative dentin and coronal or radicular pulp mineralization. In this review, we summarize what is known and/or assumed on the biological mechanisms of these therapies. We report on the effects which were obtained experimentally in rat maxillary molars by implantation of Bone Sialoprotein (BSP)/collagen pellets and Specific Amelogenin Gene Splice Products [A+4] and [A-4]) adsorbed on agarose beads. The effects were compared with those of BMP-7 (OP-1) and Ca(OH)2. Depending on the molecule that was used, we obtained either the formation of a dentin bridge, or the filling of the pulp in the mesial part of the coronal pulp chamber, or the total mineralization of the root canal. These molecules may provide new therapeutic tools in the next future in dentistry.
对生物活性分子进行直接覆盖或将这些分子植入牙髓中，可能会诱导修复性牙本质的形成以及冠髓或根髓的矿化。在本综述中，我们总结了关于这些治疗方法生物学机制的已知和/或假设内容。我们报告了通过植入吸附在琼脂糖珠上的骨唾液蛋白（BSP）/胶原蛋白微丸和特异性釉原蛋白基因剪接产物[A + 4]和[A - 4]）在大鼠上颌磨牙上实验获得的效果。将这些效果与骨形态发生蛋白-7（OP-1）和氢氧化钙的效果进行了比较。根据所使用的分子不同，我们分别获得了牙本质桥的形成、冠髓腔近中部分牙髓的填充或根管的完全矿化。这些分子可能在未来为牙科提供新的治疗工具。
