Goldberg Michel, Lacerda-Pinheiro Sally, Jegat Nadege, Six Ngampis, Septier Dominique, Priam Fabienne, Bonnefoix Mireille, Tompkins Kevin, Chardin Hélène, Denbesten Pamela, Veis Arthur, Poliard Anne
Laboratoire de Réparation et Remodelage des Tissus Oro-Faciaux, Groupe Matrices Extracellulaires et Biomineralisations, Faculté de Chirurgie Dentaire, Université René Descartes, Montrouge, France.
Dent Clin North Am. 2006 Apr;50(2):277-98, x. doi: 10.1016/j.cden.2005.11.008.
After implantation in the exposed pulp, some molecules of the den-tin extracellular matrix induce the formation of a reparative dentinal bridge in the coronal pulp. In some cases, total occlusion of the root canal also is observed. This is the case for bone sialoprotein, bone morphogenetic protein-7, Dentonin (a fragment from matrix extracellular phosphoglycoprotein), and two small amelogenin gene splice products (A+4 and A-4). Cells implicated in the reparative process are recruited, proliferate, and differentiate into osteoblast-like and odontoblast-like cells. The same results may be obtained by direct implantation of odontoblast progenitor cell into the pulp.
在植入暴露的牙髓后，一些牙本质细胞外基质分子可诱导冠髓中形成修复性牙本质桥。在某些情况下，还可观察到根管完全闭塞。骨唾液蛋白、骨形态发生蛋白-7、牙本质素（细胞外基质磷酸糖蛋白的一个片段）以及两种小的釉原蛋白基因剪接产物（A+4和A-4）就是这种情况。参与修复过程的细胞被募集、增殖并分化为成骨样细胞和成牙本质样细胞。将成牙本质祖细胞直接植入牙髓也可获得相同的结果。
