Nakagawa Yoshinobu, Pooh Kyonghon, Kobayashi Toru, Kageji Teruyoshi, Uyama Shinichi, Matsumura Akira, Kumada Hiroaki
Department of Neurosurgery, National Kagawa Children's Hospital, Zentsuji city, Kagawa, Japan.
J Neurooncol. 2003 Mar-Apr;62(1-2):87-99. doi: 10.1007/BF02699936.
Our concept of boron neutron capture therapy (BNCT) is selective destruction of tumor cells using the heavy-charged particles yielded through 10B(n, alpha)7 Li reactions. To design a new protocol that employs epithermal neutron beams in the treatment of glioma patients, we examined the relationship between the radiation dose, histological tumor grade, and clinical outcome. Since 1968, 183 patients with different kinds of brain tumors were treated by BNCT; for this retrospective study, we selected 105 patients with glial tumors who were treated in Japan between 1978 and 1997. In the analysis of side effects due to radiation, we included all the 159 patients treated between 1977 and 2001. With respect to the radiation dose (i.e. physical dose of boron n-alpha reaction), the new protocol prescribes a minimum tumor volume dose of 15 Gy or, alternatively, a minimum target volume dose of 18 Gy. The maximum vascular dose should not exceed 15 Gy (physical dose of boron n-alpha reaction) and the total amount of gamma rays should remain below 10 Gy, including core gamma rays from the reactor and capture gamma in brain tissue. The outcomes for 10 patients who were treated by the new protocol using a new mode composed of thermal and epithermal neutrons are reported.
我们对硼中子俘获疗法（BNCT）的概念是利用通过¹⁰B（n，α）⁷Li反应产生的重带电粒子选择性地破坏肿瘤细胞。为了设计一种采用超热中子束治疗胶质瘤患者的新方案，我们研究了辐射剂量、肿瘤组织学分级和临床结果之间的关系。自1968年以来，183例患有不同类型脑肿瘤的患者接受了BNCT治疗；在这项回顾性研究中，我们选择了1978年至1997年在日本接受治疗的105例胶质肿瘤患者。在分析辐射引起的副作用时，我们纳入了1977年至2001年期间接受治疗的所有159例患者。关于辐射剂量（即硼n-α反应的物理剂量），新方案规定肿瘤最小体积剂量为15 Gy，或者目标最小体积剂量为18 Gy。最大血管剂量不应超过15 Gy（硼n-α反应的物理剂量），伽马射线总量应保持在10 Gy以下，包括来自反应堆的核心伽马射线和脑组织中的俘获伽马射线。报告了10例采用由热中子和超热中子组成的新模式的新方案治疗的患者的结果。
