de Keizer R J W, de Wolff-Rouendaal D
Department of Ophthalmology, Leiden University Medical Centre, Leiden, the Netherlands.
Acta Ophthalmol Scand. 2003 Apr;81(2):193-6. doi: 10.1034/j.1600-0420.2003.00043.x.
To report the effect of topical alpha-interferon (alpha-IF) in two cases of recurrent conjunctival papillomas.
One patient with a conjunctival papilloma and one patient with a limbus-based papilloma were treated with excision and cryotherapy. Recurrences included one in situ carcinoma. Retreatment included systemic and topical alpha-IF.
In Case 1, the papillomas regressed with systemic alpha-IF followed by topical application of alpha-IF (2.8 x 106 U) for 1 year against recurrence. In Case 2, the papillomas disappeared with topical alpha-IF over 1 year. No recurrences were seen during follow-up (84 and 91 months, respectively). The possible side effect of topical alpha-IF was superficial keratitis. Retrospective polymerase chain reaction tests for HPV were positive and showed type 6 in Case 1 and type 33 in Case 2.
Topical alpha-IF can be used as adjuvant therapy in recurrent conjunctival papillomas.
报告局部应用α-干扰素（α-IF）治疗两例复发性结膜乳头状瘤的效果。
一名结膜乳头状瘤患者和一名角膜缘乳头状瘤患者接受了切除及冷冻治疗。复发包括一例原位癌。再次治疗包括全身及局部应用α-IF。
病例1中，乳头状瘤在全身应用α-IF后消退，随后局部应用α-IF（2.8×10⁶U）持续1年以预防复发。病例2中，乳头状瘤在局部应用α-IF超过1年后消失。随访期间（分别为84个月和91个月）未见复发。局部应用α-IF可能的副作用是浅层角膜炎。HPV的回顾性聚合酶链反应检测呈阳性，病例1显示为6型，病例2显示为33型。
局部应用α-IF可作为复发性结膜乳头状瘤的辅助治疗。
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