Taylor C R, Hawk J L
Department of Photobiology, St John's Institute of Dermatology, St Thomas' Hospital, London, U.K.
Br J Dermatol. 1995 Dec;133(6):914-8. doi: 10.1111/j.1365-2133.1995.tb06925.x.
Our 10-year experience with PUVA treatment for alopecia areata, partialis, totalis and universalis was retrospectively reviewed using charts and follow-up questionnaires for 70 patients at St John's Institute of Dermatology. In all cases, several previous therapies were judged to be unsatisfactory prior to starting PUVA, and many cases were already deemed clinically refractory prior to referral for PUVA. If cases of vellus hair growth are excluded, and those who lost their PUVA-induced regrowth rapidly on follow-up, the effective success rate was at best 6.3% for alopecia areata partialis, 12.5% for alopecia areata totalis and 13.3% for alopecia areata universalis. We affirm that PUVA is generally not an effective treatment for alopecia areata.
我们回顾性分析了在圣约翰皮肤病研究所对70例斑秃（包括局限性、全秃和普秃）患者进行光化学疗法（PUVA）治疗的10年经验，使用病历和随访问卷进行研究。在所有病例中，在开始PUVA治疗之前，几种先前的治疗方法均被判定为不满意，并且许多病例在转诊接受PUVA治疗之前就已被临床判定为难治性。如果排除毳毛生长的病例以及那些在随访中很快失去PUVA诱导的毛发再生的病例，局限性斑秃的有效成功率最高为6.3%，全秃为12.5%，普秃为13.3%。我们断言，PUVA通常不是斑秃的有效治疗方法。
