Moolchan Eric T, Aung A Thiri, Henningfield Jack E
Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA.
Drug Alcohol Depend. 2003 Jun 5;70(3):223-32. doi: 10.1016/s0376-8716(03)00012-7.
The cycle of tobacco dependence typically begins with the initiation of tobacco use during adolescence. Many teenagers try to quit smoking, fail and subsequently desire treatment for their tobacco dependence. Adolescents do not currently benefit from the same level of societal support for quit attempts as adults, and they may be less motivated for total cessation despite the short and long-term health consequences of smoking. Overall, the combination of low participation, high attrition and low complete cessation rates for adolescent smokers in treatment prompts the consideration of alternative treatment endpoints. It is likely that interactions among the processes of child and adolescent development, smoke exposure and trajectory influence patterns of tobacco use and treatment for tobacco dependence in adolescents. A rational framework is needed to integrate the study of these dynamic interactions to address tobacco dependence among youth from an exposure reduction, in addition to a cessation, perspective. This paper considers the issues and potential implications of tobacco exposure reduction therapy as an intermediate treatment goal for adolescent smokers who are dependent or dependence-prone, but for whom initial treatment interventions do not yield complete tobacco cessation.
烟草依赖的循环通常始于青少年时期开始使用烟草。许多青少年试图戒烟,但失败了,随后渴望治疗他们的烟草依赖。目前,青少年在戒烟尝试中并未像成年人那样从同等程度的社会支持中受益,而且尽管吸烟会带来短期和长期的健康后果,但他们完全戒烟的动力可能较小。总体而言,青少年吸烟者在治疗中的低参与度、高脱落率和低完全戒烟率促使人们考虑采用替代治疗终点。儿童和青少年发育过程、烟雾暴露和轨迹之间的相互作用很可能会影响青少年的烟草使用模式和烟草依赖治疗。需要一个合理的框架来整合对这些动态相互作用的研究,以便从减少暴露以及戒烟的角度来解决青少年的烟草依赖问题。本文探讨了将减少烟草暴露疗法作为依赖或易依赖烟草的青少年吸烟者的中间治疗目标所涉及的问题和潜在影响,这些青少年最初的治疗干预未能实现完全戒烟。