血红素在吡啶/水混合物中的结构及其在血红素分解代谢研究中的意义。
The structure of haem in pyridine/water mixtures and its implication in studies of haem catabolism.
作者信息
Brown S B, King R F
出版信息
Biochem J. 1976 Feb 1;153(2):479-83. doi: 10.1042/bj1530479.
Abstract
- A study of haem spectra in pyridine/water mixtures at low pyridine concentrations revealed changes in haemochrome structure consistent with an aggregation process. No corresponding change in the structure of the haemichrome species was observed. 2. This aggregation has been correlated with a previously observed sharp decrease in the rate of coupled oxidation (degradation) of haem as pyridine concentration is decreased. The decrease appears to be due primarily to haem aggregation and not to changes in the hydrophobic nature of the solvent. The effect of ethanol and butanone addition was examined and supports this conclusion. 3. Evidence is presented that coupled oxidation occurs via the iron (II) species (haemochrome).
摘要
- 一项对低吡啶浓度下吡啶/水混合物中血红素光谱的研究表明，高铁血红素结构的变化与聚集过程一致。未观察到高铁血红素物种结构的相应变化。2. 这种聚集与之前观察到的随着吡啶浓度降低血红素偶联氧化（降解）速率的急剧下降有关。这种下降似乎主要是由于血红素聚集，而非溶剂疏水性质的变化。对添加乙醇和丁酮的影响进行了研究，结果支持这一结论。3. 有证据表明偶联氧化是通过亚铁（II）物种（高铁血红素）发生的。
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