立体特异性血红素裂解。体内和体外胆汁色素异构体形成的模型。
Stereospecific haem cleavage. A model for the formation of bile-pigment isomers in vivo and in vitro.
作者信息
Brown S B
出版信息
Biochem J. 1976 Oct 1;159(1):23-7. doi: 10.1042/bj1590023.
Abstract
A new approach is suggested for an explanation of sterospecific haem degradation to biliverdin and bilirubin. A model is proposed in which an oxygen molecule, bound to the haem iron atom, attacks a methene-bridge carbon atom in an intramolecular reaction. Specificity of macrocyclic ring cleavage is explained on the basis of the different accessibilities of the bound oxygen molecule to the four methene bridges. The consequences of these ideas are assessed in relation to coupled oxidation in model systems and to haem catabolism.
摘要
提出了一种新方法来解释血红素向胆绿素和胆红素的立体特异性降解。提出了一个模型，其中与血红素铁原子结合的氧分子在分子内反应中攻击一个亚甲基桥碳原子。基于结合的氧分子对四个亚甲基桥的不同可及性来解释大环环裂解的特异性。根据模型系统中的偶联氧化和血红素分解代谢对这些观点的结果进行了评估。
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本文引用的文献
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