Gaudreau Christiane, Gilbert Huguette
Département de Microbiologie Médicale et Infectiologie, Hôpital Saint-Luc, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada H2X 3J4.
Antimicrob Agents Chemother. 2003 Jun;47(6):2027-9. doi: 10.1128/AAC.47.6.2027-2029.2003.
The rates of resistance of 51 to 72 human strains of Campylobacter jejuni subsp. jejuni isolated annually from 1998 to 2001 in Montréal, Québec, Canada, varied from 1 to 12% for erythromycin, 43 to 68% for tetracycline, and 10 to 47% for ciprofloxacin. In the last years of the study, there was a significant increase in the rate of resistance to ciprofloxacin (P = 0.00003) but not in the rate of resistance to erythromycin (P = 0.056) or tetracycline (P = 0.095) compared to the rate obtained in the first years. All 51 C. jejuni strains isolated in 2001 were susceptible to gentamicin, amoxicillin-clavulanic acid, imipenem, and meropenem. From 1999 to 2001, 74 strains of C. jejuni acquired abroad were significantly more resistant to ciprofloxacin than 109 strains of C. jejuni acquired locally (66 versus 9%, P < 0.00001) but were not significantly more resistant to erythromycin (1 versus 6%, P = 0.15) or to tetracycline (55 versus 58%, P = 0.87).
1998年至2001年期间，每年从加拿大魁北克省蒙特利尔分离出51至72株空肠弯曲菌空肠亚种的人源菌株，其中红霉素的耐药率为1%至12%，四环素为43%至68%，环丙沙星为10%至47%。在研究的最后几年，与最初几年相比，环丙沙星的耐药率显著增加（P = 0.00003），但红霉素（P = 0.056）或四环素（P = 0.095）的耐药率没有显著增加。2001年分离出的所有51株空肠弯曲菌菌株对庆大霉素、阿莫西林-克拉维酸、亚胺培南和美罗培南均敏感。1999年至2001年，从国外获得的74株空肠弯曲菌菌株对环丙沙星的耐药性明显高于在当地获得的109株空肠弯曲菌菌株（分别为66%和9%，P < 0.00001），但对红霉素（分别为1%和6%，P = 0.15）或四环素（分别为55%和58%，P = 0.87）的耐药性没有显著差异。
