Gaudreau C, Gilbert H
Département de Microbiologie Médicale et Infectiologie, Campus Saint-Luc, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada H2X 3J4.
Antimicrob Agents Chemother. 1998 Aug;42(8):2106-8. doi: 10.1128/AAC.42.8.2106.
The antimicrobial resistance of 158 Campylobacter jejuni strains isolated from humans in Quebec, Canada, from 1995 to 1997 was compared to the resistance of 47 and 86 strains of C. jejuni isolated in 1985 and 1986 and in 1992 and 1993, respectively. Of the 291 C. jejuni strains tested, no strain was resistant to erythromycin. Compared to the C. jejuni strains isolated in 1985 and 1986, the C. jejuni strains isolated in 1992 and 1993 were more resistant to tetracycline (40.7 versus 19.1%, respectively; P = 0. 01) but not to nalidixic acid or ciprofloxacin (P > 0.05). Compared to the C. jejuni strains isolated in 1992 and 1993 and in 1985 and 1986, the C. jejuni strains isolated from 1995 to 1997 were more resistant to tetracycline (55.7% versus 40.7 and 19.1%, respectively; P = 0.03 and P < 0.001, respectively) to nalidixic acid (13.9% versus 4.7 and 0%, respectively; P = 0.02 and P = 0.007, respectively), and to ciprofloxacin (12.7% versus 3.5 and 0%, respectively; P = 0.02 and P = 0.009, respectively).
将1995年至1997年从加拿大魁北克省人类分离出的158株空肠弯曲菌菌株的抗菌耐药性，与分别在1985年和1986年以及1992年和1993年分离出的47株和86株空肠弯曲菌菌株的耐药性进行了比较。在测试的291株空肠弯曲菌菌株中，没有菌株对红霉素耐药。与1985年和1986年分离出的空肠弯曲菌菌株相比，1992年和1993年分离出的空肠弯曲菌菌株对四环素的耐药性更高（分别为40.7%和19.1%；P = 0.01），但对萘啶酸或环丙沙星的耐药性没有差异（P > 0.05）。与1992年和1993年以及1985年和1986年分离出的空肠弯曲菌菌株相比，1995年至1997年分离出的空肠弯曲菌菌株对四环素的耐药性更高（分别为55.7%、40.7%和19.1%；P分别为0.03和<0.001），对萘啶酸的耐药性更高（分别为13.9%、4.7%和0%；P分别为0.02和0.007），对环丙沙星的耐药性更高（分别为12.7%、3.5%和0%；P分别为0.02和0.009）。
