Gerasimenko Yu P, Avelev V D, Nikitin O A, Lavrov I A
Motor Physiology Laboratory, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia.
Neurosci Behav Physiol. 2003 Mar;33(3):247-54. doi: 10.1023/a:1022199214515.
Acute and chronic experiments on lower spinal (T10-T12) cats were performed to investigate the effects of epidural stimulation of the dorsal surface of the spinal cord on the initiation of locomotor activity. A zone located at the border between segments L4 and L5 was identified, stimulation of which induces locomotor activity. The parameters of epidural stimulation of the spinal cord effective in activating the stepping movement generator were identified. Epidural stimulation leading to the initiation of movement activity was shown to depend on intracentral and peripheral mechanisms activating the segmental, intersegmental and propriospinal reflex systems of the spinal cord. A leading role was demonstrated for the propriospinal system of the dorsolateral funiculi in activating the generators of stepping movements in epidural stimulation of the spinal cord.
对低位脊髓(T10 - T12)猫进行急性和慢性实验,以研究硬膜外刺激脊髓背面对运动活动起始的影响。确定了位于L4和L5节段边界的一个区域,刺激该区域可诱发运动活动。确定了硬膜外刺激脊髓有效激活踏步运动发生器的参数。导致运动活动起始的硬膜外刺激被证明依赖于激活脊髓节段性、节段间和脊髓固有反射系统的中枢内和外周机制。在脊髓硬膜外刺激激活踏步运动发生器方面,背外侧索的脊髓固有系统发挥了主导作用。