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硬膜外刺激脊髓引发脊髓猫的运动活动

Initiation of locomotor activity in spinal cats by epidural stimulation of the spinal cord.

作者信息

Gerasimenko Yu P, Avelev V D, Nikitin O A, Lavrov I A

机构信息

Motor Physiology Laboratory, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia.

出版信息

Neurosci Behav Physiol. 2003 Mar;33(3):247-54. doi: 10.1023/a:1022199214515.

DOI:10.1023/a:1022199214515
PMID:12762591
Abstract

Acute and chronic experiments on lower spinal (T10-T12) cats were performed to investigate the effects of epidural stimulation of the dorsal surface of the spinal cord on the initiation of locomotor activity. A zone located at the border between segments L4 and L5 was identified, stimulation of which induces locomotor activity. The parameters of epidural stimulation of the spinal cord effective in activating the stepping movement generator were identified. Epidural stimulation leading to the initiation of movement activity was shown to depend on intracentral and peripheral mechanisms activating the segmental, intersegmental and propriospinal reflex systems of the spinal cord. A leading role was demonstrated for the propriospinal system of the dorsolateral funiculi in activating the generators of stepping movements in epidural stimulation of the spinal cord.

摘要

对低位脊髓(T10 - T12)猫进行急性和慢性实验,以研究硬膜外刺激脊髓背面对运动活动起始的影响。确定了位于L4和L5节段边界的一个区域,刺激该区域可诱发运动活动。确定了硬膜外刺激脊髓有效激活踏步运动发生器的参数。导致运动活动起始的硬膜外刺激被证明依赖于激活脊髓节段性、节段间和脊髓固有反射系统的中枢内和外周机制。在脊髓硬膜外刺激激活踏步运动发生器方面,背外侧索的脊髓固有系统发挥了主导作用。

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1
Initiation of locomotor activity in spinal cats by epidural stimulation of the spinal cord.硬膜外刺激脊髓引发脊髓猫的运动活动
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本文引用的文献

1
SPINAL REFLEXES AND MONOAMINE LIBERATION.脊髓反射与单胺释放
Nature. 1964 Jun 20;202:1222-3. doi: 10.1038/2021222a0.
2
Crossed reflexes of cutaneous origin.皮肤源性交叉反射。
Am J Physiol. 1957 Mar;188(3):609-15. doi: 10.1152/ajplegacy.1957.188.3.609.
3
Evidence for a spinal central pattern generator in humans.人类脊髓中枢模式发生器的证据。
治疗策略针对脊髓损伤后的呼吸恢复:从临床前开发到临床转化。
Cells. 2023 May 31;12(11):1519. doi: 10.3390/cells12111519.
4
When Spinal Neuromodulation Meets Sensorimotor Rehabilitation: Lessons Learned From Animal Models to Regain Manual Dexterity After a Spinal Cord Injury.当脊髓神经调节与感觉运动康复相遇:从动物模型中汲取的经验教训,以恢复脊髓损伤后的手部灵巧性。
Front Rehabil Sci. 2021 Dec 7;2:755963. doi: 10.3389/fresc.2021.755963. eCollection 2021.
5
Differences in backward and forward treadmill locomotion in decerebrated cats.去大脑猫在后退和前进跑步机运动中的差异。
J Exp Biol. 2022 May 1;225(9). doi: 10.1242/jeb.244210. Epub 2022 May 11.
6
Electrical epidural stimulation of the cervical spinal cord: implications for spinal respiratory neuroplasticity after spinal cord injury.颈椎硬膜外电刺激:对脊髓损伤后脊髓呼吸神经可塑性的影响。
J Neurophysiol. 2021 Aug 1;126(2):607-626. doi: 10.1152/jn.00625.2020. Epub 2021 Jul 7.
7
Epidural electrical stimulation for spinal cord injury.脊髓损伤的硬膜外电刺激
Neural Regen Res. 2021 Dec;16(12):2367-2375. doi: 10.4103/1673-5374.313017.
8
Innovations in electrical stimulation harness neural plasticity to restore motor function.电刺激方面的创新利用神经可塑性来恢复运动功能。
Bioelectron Med (Lond). 2018 Dec;1(4):251-263. doi: 10.2217/bem-2019-0002. Epub 2019 Apr 24.
9
Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment.硬膜外刺激联合三重基因治疗治疗脊髓损伤。
Int J Mol Sci. 2020 Nov 24;21(23):8896. doi: 10.3390/ijms21238896.
10
Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs.联合病灶上和病灶下硬膜外电刺激用于小型猪脊髓损伤后运动功能的恢复
Brain Sci. 2020 Oct 16;10(10):744. doi: 10.3390/brainsci10100744.
Ann N Y Acad Sci. 1998 Nov 16;860:360-76. doi: 10.1111/j.1749-6632.1998.tb09062.x.
4
[Stepping movements caused by stimulation of the cat spinal cord dorsolateral funiculus].[猫脊髓背外侧索刺激引起的踏步运动]
Biull Eksp Biol Med. 1983 Aug;96(8):8-10.
5
The capacity for generation of rhythmic oscillations is distributed in the lumbosacral spinal cord of the cat.产生节律性振荡的能力分布在猫的腰骶脊髓中。
Exp Brain Res. 1983;53(1):81-90. doi: 10.1007/BF00239400.
6
[Control of walking and running by means of electric stimulation of the midbrain].[通过中脑电刺激控制行走和跑步]
Biofizika. 1966;11(4):659-66.
7
The effect of DOPA on the spinal cord. 2. A pharmacological analysis.多巴对脊髓的作用。2. 药理学分析。
Acta Physiol Scand. 1966 Jul-Aug;67(3):387-97. doi: 10.1111/j.1748-1716.1966.tb03325.x.
8
[Stepping movements in the spinal cat after DOPA injection].
Fiziol Zh SSSR Im I M Sechenova. 1973 Aug;59(8):1190-8.
9
The effect of DOPA on the spinal cord. 6. Half-centre organization of interneurones transmitting effects from the flexor reflex afferents.多巴对脊髓的作用。6. 传递屈肌反射传入效应的中间神经元的半中枢组织。
Acta Physiol Scand. 1967 Jul-Aug;70(3):389-402. doi: 10.1111/j.1748-1716.1967.tb03637.x.
10
A theoretical study of epidural electrical stimulation of the spinal cord--Part I: Finite element analysis of stimulus fields.
IEEE Trans Biomed Eng. 1985 Nov;32(11):971-7. doi: 10.1109/tbme.1985.325648.