Davies-Coleman Michael T, Dzeha Thomas M, Gray Christopher A, Hess Sonja, Pannell Lewis K, Hendricks Denver T, Arendse Catherine E
Department of Chemistry, Rhodes University, Grahamstown, South Africa.
J Nat Prod. 2003 May;66(5):712-5. doi: 10.1021/np030014t.
An examination of an organic extract of the cyanobacterium Lyngbya majuscula, collected from Wasini Island off the southern Kenyan coast, led to the isolation of the known cyclic depsipeptide antanapeptin A (1), recently isolated from a Madagascan collection of L. majuscula, and a new bioactive cyclic depsipeptide, homodolastatin 16 (2). The structures of these two compounds were determined from NMR and mass spectrometry data. Homodolastatin 16, a higher homologue of the potential anticancer agent dolastatin 16, exhibited moderate activity against oesophageal and cervical cancer cell lines.
对从肯尼亚南部海岸瓦西尼岛采集的蓝藻巨大鞘丝藻的有机提取物进行研究后，分离出了已知的环缩肽安他那肽A（1），该物质最近从马达加斯加采集的巨大鞘丝藻中分离得到，同时还分离出了一种新的具有生物活性的环缩肽，即高同型多拉司他汀16（2）。这两种化合物的结构通过核磁共振和质谱数据确定。高同型多拉司他汀16是潜在抗癌药物多拉司他汀16的一种更高同系物，对食管和宫颈癌细胞系表现出中等活性。
