Jarrett E E, Haig D M
Clin Exp Immunol. 1976 May;24(2):346-51.
We present here a study of the relationship in time between the elevation of total serum IgE, the parasite-specific IgE response, and the potentiated IgE response to unrelated antigen which occurs in rats following infection with the worm parasite N. brasiliensis. During a first infection the potentiated IgE response (to egg albumin) and elevation of total IgE occur synchronously rising to a peak on days 12-14 after infection, with the fastest rate of increase occurring between days 8 and 10. N. brasiliensis-specific IgE rises to a peak some 2-3 weeks later when both total IgE and the potentiated response have largely declined. A strain difference is shown in that Wistar rats produce far lower levels of total and parasite-specific IgE than Hooded Listers. Events following reinfection differ in that total IgE rises more rapidly, very high levels being reached 6 days after reinfected together with a secondary specific IgE response to N. brasiliensis. The total IgE level, however, rises by a far greater factor than parasite-specific IgE and declines rapidly while the parasite-specific response declines slowly over many weeks. The egg albumin response is not repotentiated. It is proposed that the total IgE response and the potentiated IgE response which forms a small component of it results from the release of a non-specific IgE-stimulating factor produced by N. brasiliensis-specific T cells. In this scheme the same or similar cells are involved in the production of N. brasiliensis-specific IgE through a separate specific helper function.
我们在此展示了一项关于感染巴西日圆线虫的大鼠体内，总血清IgE升高、寄生虫特异性IgE反应以及对无关抗原的增强IgE反应之间时间关系的研究。在初次感染期间，增强的IgE反应（针对卵清蛋白）和总IgE升高同步发生，在感染后第12 - 14天达到峰值，最快的升高速率出现在第8天至第10天之间。巴西日圆线虫特异性IgE在大约2 - 3周后达到峰值，此时总IgE和增强反应已大幅下降。研究显示出一种品系差异，即Wistar大鼠产生的总IgE和寄生虫特异性IgE水平远低于带帽利斯特大鼠。再次感染后的情况有所不同，总IgE升高更快，在再次感染后6天达到非常高的水平，同时伴随着对巴西日圆线虫的二次特异性IgE反应。然而，总IgE水平的升高幅度远大于寄生虫特异性IgE，并且迅速下降，而寄生虫特异性反应在数周内缓慢下降。对卵清蛋白的反应没有再次增强。有人提出，总IgE反应以及构成其一小部分的增强IgE反应是由巴西日圆线虫特异性T细胞产生的一种非特异性IgE刺激因子的释放所导致。在这个机制中，相同或相似的细胞通过一种单独的特异性辅助功能参与巴西日圆线虫特异性IgE的产生。
