正常大鼠和感染巴西日圆线虫的大鼠中IgE和IgGa抗体的产生。
The production of IgE and IgGa antibodies in normal rats and rats infected with Nippostrongylus brasiliensis.
作者信息
Meacock S C, Marsden C H
出版信息
Immunology. 1976 Apr;30(4):491-6.
The time courses of production of IgE and IgGa homocytotropic antibodies were measured in Wistar rats during a primary and secondary response to egg albumin with pertussis or Freund's adjuvants. An anamnestic IgE antibody response occurred in animals previously sensitized to antigen with killed Bordetella pertussis as adjuvant. IgGa antibodies were formed in the primary response with Freund's complete adjuvant only, but were found during the secondary response with all adjuvants used. The time courses of formation of IgE and IgGa antibodies were very different during the secondary response. The production of both classes of antibody to egg albumin was studed in Wistar and Hooded Lister rats infected with Nippostrongylus brasiliensis. IgGa antibody formation was not potentiated by the infection. However, increased levels of IgE antibody, formed during a secondary response to antigen in infected animals, were consistently higher in both strains than during a primary response.
在对卵清蛋白产生初次和二次应答期间，用百日咳或弗氏佐剂处理Wistar大鼠，测定其IgE和IgGa亲同种细胞抗体的产生时间进程。用灭活的百日咳杆菌作为佐剂预先致敏抗原的动物中出现了回忆性IgE抗体应答。IgGa抗体仅在初次应答中与弗氏完全佐剂一起形成，但在二次应答中使用所有佐剂时均可发现。在二次应答期间，IgE和IgGa抗体的形成时间进程非常不同。在感染巴西日圆线虫的Wistar和带帽利斯特大鼠中研究了针对卵清蛋白的这两类抗体的产生。感染并未增强IgGa抗体的形成。然而，在感染动物中对抗原产生二次应答期间形成的IgE抗体水平升高，在两个品系中均始终高于初次应答期间。
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