p53在皮肤鳞状细胞癌免疫生物学中的作用。
The role of p53 in the immunobiology of cutaneous squamous cell carcinoma.
作者信息
Black A P B, Ogg G S
机构信息
University of Oxford, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe Hospital, UK.
出版信息
Clin Exp Immunol. 2003 Jun;132(3):379-84. doi: 10.1046/j.1365-2249.2003.02159.x.
Abstract
Cutaneous squamous cell carcinoma is typically characterized by the over-expression of the tumour suppressor protein p53. Considerable evidence suggests that immune competence is important in the control of cutaneous SCC. We discuss the immunobiology of p53 and its relevance to cutaneous SCC, including the potential interaction with human papillomavirus.
摘要
皮肤鳞状细胞癌的典型特征是肿瘤抑制蛋白p53的过度表达。大量证据表明，免疫能力在皮肤鳞状细胞癌的控制中起着重要作用。我们将讨论p53的免疫生物学及其与皮肤鳞状细胞癌的相关性，包括其与人类乳头瘤病毒的潜在相互作用。
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