Alford R H, Cartwright B B, Sell S H
Infect Immun. 1976 Apr;13(4):1170-5. doi: 10.1128/iai.13.4.1170-1175.1976.
Thymidine uptake of unstimulated and of phytohemagglutinin (PHA)-, streptokinase-streptodornase (SK-SD)- and candida extract (candida)-stimulated lymphocytes of normal infants less than 20 months old was evaluated. Thymidine uptake of unstimulated and PHA-stimulated young infants' lymphocytes was avid, resembling that of newborn cells. Over periods of weeks to months, infantile lymphocytes demonstrated transition in unstimulated and PHA-induced thymidine uptake from response patterns like cord blood cells to ones more characteristic of adult lymphocytes. Candida- and SK-SD-induced thymidine uptake of lymphocytes from very young infants was likewise apparently quite avid, resembling cord blood cells. However, factoring out high unstimulated thymidine uptake by conversion of data to stimulation indexes clarified differing paces of acquisition of transformation responsiveness of the two naturally acquired infectious antigens. Specific lymphocytes reactivity to SK-SD was quite low in all groups of infants compared with candida-induced transformation, which in some infants acquired adult proportions.
对20个月以下正常婴儿未受刺激的淋巴细胞以及受植物血凝素（PHA）、链激酶-链道酶（SK-SD）和念珠菌提取物（念珠菌）刺激的淋巴细胞的胸腺嘧啶核苷摄取情况进行了评估。未受刺激的和PHA刺激的幼儿淋巴细胞对胸腺嘧啶核苷的摄取很活跃，类似于新生儿细胞。在数周至数月的时间里，婴儿淋巴细胞在未受刺激的和PHA诱导的胸腺嘧啶核苷摄取方面，从类似脐血细胞的反应模式转变为更具成人淋巴细胞特征的模式。来自非常小的婴儿的淋巴细胞对念珠菌和SK-SD诱导的胸腺嘧啶核苷摄取同样明显很活跃，类似于脐血细胞。然而，通过将数据转换为刺激指数来排除未受刺激时较高的胸腺嘧啶核苷摄取，明确了两种自然获得的感染性抗原转化反应性获得的不同速度。与念珠菌诱导的转化相比，所有婴儿组中淋巴细胞对SK-SD的特异性反应相当低，在一些婴儿中念珠菌诱导的转化达到了成人水平。
