Friedmann P S
Clin Exp Immunol. 1977 Nov;30(2):271-6.
Thirty-eight mothers and babies were assessed by the lymphocyte transformation test for their cell-mediated immune responses to Treponema pallidum and to purified protein derivative of tuberculin (PPD). All babies, including controls, appeared to be reactive when results of [3H]-thymidine incorporation were expressed as net counts per minute. This was because of high background activity, which was most marked in cells from neonates. When results were expressed as stimulation ratios, it was revealed that cells from neonates were unreactive to both antigens, even when those from their mothers were reactive. Cells from some older babies with active congenital syphilis were reactive to both antigens.
通过淋巴细胞转化试验对38对母婴进行了评估，以检测她们对梅毒螺旋体和结核菌素纯蛋白衍生物（PPD）的细胞介导免疫反应。当将[3H] - 胸腺嘧啶核苷掺入结果表示为每分钟净计数时，所有婴儿，包括对照组，似乎都有反应。这是因为背景活性很高，在新生儿的细胞中最为明显。当结果表示为刺激率时，发现即使母亲的细胞有反应，新生儿的细胞对这两种抗原均无反应。一些患有活动性先天性梅毒的较大婴儿的细胞对这两种抗原均有反应。
