Franzé Annamaria, Sequino Luigi, Saulino Claudio, Attanasio Giuseppe, Marciano Elio
International Institute of Genetics and Biophysics, CNR, Naples, Italy.
Int J Audiol. 2003 Jun;42(4):227-34. doi: 10.3109/14992020309101318.
Temporary threshold shift (TTS) and permanent threshold shift (PTS) may follow prolonged noise exposure. Several reports suggest that noise-induced damage to the cochlea may be related to the activity of reactive oxygen species (ROS). Drugs that scavenge or block ROS formation also protect the cochlea. Guinea pigs, treated with allopurinol, were exposed to white noise (120 dB SPL) or impulse noise (114 dB SPL) for 2 and 5 h. The protective effect of allopurinol was confirmed, but, at these levels of sound, it was present only after noise exposure up to 2 h. This study also offers evidence suggesting that allopurinol does not influence the establishment of PTS.
长期暴露于噪声中可能会导致暂时性阈移（TTS）和永久性阈移（PTS）。多项报告表明，噪声引起的耳蜗损伤可能与活性氧（ROS）的活性有关。清除或阻断ROS形成的药物也能保护耳蜗。用别嘌醇治疗的豚鼠暴露于白噪声（120 dB SPL）或脉冲噪声（114 dB SPL）中2小时和5小时。别嘌醇的保护作用得到了证实，但在这些声级下，仅在暴露噪声达2小时后才出现这种保护作用。本研究还提供了证据表明别嘌醇不会影响PTS的形成。
