健康成年人群中血清白细胞介素18水平与血脂及血糖浓度的关系。
Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population.
作者信息
Olusi S O, Al-Awadhi A, Abraham M
机构信息
Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait.
出版信息
Horm Res. 2003;60(1):29-33. doi: 10.1159/000070824.
AIM
To investigate the associations between serum interleukin (IL) 18 concentrations and indices of lipid and carbohydrate metabolism in healthy adults.
METHODS
Fasting serum concentrations of IL-18, glucose, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterols were measured in 570 apparently healthy adults.
RESULTS
Univariate linear and partial regression analyses showed that the serum IL-18 concentration was positively correlated with serum triglyceride and glucose concentrations in both obese and diabetic subjects after controlling for the confounding effects of age, sex, and body mass index.
CONCLUSION
IL-18 may be associated with obesity and glucose intolerance.
目的
研究健康成年人血清白细胞介素（IL）-18浓度与脂质和碳水化合物代谢指标之间的关联。
方法
对570名表面健康的成年人测量其空腹血清中IL-18、葡萄糖、总胆固醇、甘油三酯以及高密度和低密度脂蛋白胆固醇的浓度。
结果
单变量线性和偏回归分析显示，在控制年龄、性别和体重指数的混杂效应后，肥胖和糖尿病受试者的血清IL-18浓度与血清甘油三酯和葡萄糖浓度呈正相关。
结论
IL-18可能与肥胖和葡萄糖不耐受有关。
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