Freeman Ellen W, Sammel Mary D, Liu Li, Martin Paula
Department of Obstetrics/Gynecology, University of Pennsylvania, Philadelphia 19104, USA.
Menopause. 2003 May-Jun;10(3):258-65. doi: 10.1097/00042192-200310030-00014.
To determine psychometric properties of a brief menopause symptom list and its sensitivity to menopausal status in a population-based cohort of late reproductive-age women.
A 12-item menopause symptom list (MSL) administered in a cohort of African American and Caucasian women aged 38 to 52 years (N = 350) was psychometrically evaluated. Menopausal status of the cohort was determined by menstrual cycle dates obtained in interviews and participants' daily symptom records. Results of factor analysis were applied to longitudinal assessments of the cohort over a 3-year period. Convergent validity with other standard measures of mood, stress, health, and quality of life was determined.
Internal consistency was found for the MSL items. Item total correlations are reported. Factor analysis identified three dimensions (psychological, somatic, and vasomotor). Multivariate analysis of cohort data over a 3-year interval showed that the menopausal symptoms increased over time (P = 0.0004) and that the identified factors were differentially associated with menopausal status. Psychological symptoms increased in the premenopausal and early transition groups but decreased in the late menopausal-postmenopausal groups (P = 0.0046 for the interaction). Vasomotor symptoms increased in both the early transition and late menopausal-postmenopausal groups (P = 0.0309 and P = 0.0543, respectively). Psychological symptoms (factor 1) had high correlations with other standard symptom measures (Center for Epidemiologic Studies-Depression Scale, r = 0.59; Zung Anxiety Scale, r = 0.65), whereas factors 2 and 3 did not, suggesting that the somatic and vasomotor symptoms were not associated with mood or health problems.
The MSL provides a brief questionnaire with acceptable psychometric properties for assessing three dimensions of menopause-related symptoms and demonstrated sensitivity to menopausal status in a population-based cohort.
在一个基于人群的晚生育年龄女性队列中，确定一份简短的更年期症状清单的心理测量特性及其对更年期状态的敏感性。
对38至52岁的非裔美国人和白人女性队列（N = 350）进行了一项包含12个项目的更年期症状清单（MSL）的心理测量评估。该队列的更年期状态通过访谈中获得的月经周期日期和参与者的每日症状记录来确定。将因子分析的结果应用于该队列3年期间的纵向评估。确定了与情绪、压力、健康和生活质量的其他标准测量方法的收敛效度。
发现MSL项目具有内部一致性。报告了项目与总分的相关性。因子分析确定了三个维度（心理、躯体和血管舒缩）。对该队列3年期间的数据进行的多变量分析表明，更年期症状随时间增加（P = 0.0004），并且所确定的因子与更年期状态存在差异关联。心理症状在绝经前和早期过渡组中增加，但在绝经后期 - 绝经后组中减少（交互作用的P = 0.0046）。血管舒缩症状在早期过渡组和绝经后期 - 绝经后组中均增加（分别为P = 0.0309和P = 0.0543）。心理症状（因子1）与其他标准症状测量方法具有高度相关性（流行病学研究中心抑郁量表，r = 0.59；zung焦虑量表，r = 0.65），而因子2和3则不然，这表明躯体和血管舒缩症状与情绪或健康问题无关。
MSL提供了一份具有可接受心理测量特性的简短问卷，用于评估更年期相关症状的三个维度，并在基于人群的队列中显示出对更年期状态的敏感性。
