Lillie Elizabeth O, Bernstein Leslie, Ursin Giske
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Breast Cancer Res. 2003;5(3):164-73. doi: 10.1186/bcr593. Epub 2003 Apr 2.
Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Paradoxically, results from observational studies that have examined polymorphisms in the androgen receptor suggest that the low-activity androgen receptor increases breast cancer risk. We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide.
睾酮与靶组织中的雄激素受体结合以介导其作用。睾酮水平和雄激素受体活性的变化可能在乳腺癌的病因学中起作用。在此，我们综述了将内源性睾酮与乳腺癌风险联系起来的流行病学证据。矛盾的是，对雄激素受体多态性进行研究的观察性研究结果表明，低活性雄激素受体增加乳腺癌风险。我们评估了该证据的质量，并在最后讨论了雄激素受体和睾酮的研究结果是如何一致的。
