Morphogenesis and pathogenesis of chronic lung diseases. vii. Kinetics of alkaline phosphatase active cells during the development of experimental lung granulomas.

The circulating cells arriving at the formation site of the experimentally induced lung granuloma were quantitatively and qualitatively determined during their development by estimation of alkaline phosphatase active free cells. These represent 32 per cent the 2nd day and 27 per cent the 4th, of all the lung granuloma cells, and rapidly decrease to 8 per cent the 8th day, to 4 per cent the 11th and to only 1.5 per cent the 15th day. The participation of alkaline phosphatase circulating cells appears to be important only the first days, the process becoming by proliferation and differentiation a histiocytic, epithelioidic, and lympho-plasmocytic structure under the influence of antigenic and non-antigenic components of the used immunologic adjuvant.