Eskenasy A, Tapu V, Marinescu D
Med Interne. 1979 Apr-Jun;17(2):175-85.
The stereotyped development and the cellular kinetics of lung granulomas experimentally-induced in rabbits by an intravenous injection of the complete Freund adjuvant with addition of human gammaglobulin, were studied under the influence of hydrocortisone acetate, rifampicin, heparin and phenobarbital. As in a previous study using actinomycin and puromycin, the analysed drugs delayed up to inhibition (hydrocortisone) the development of lung granulomas which remained small, unfused, without epithelioidosis; the primary and secondary immune responses were more or less influenced up to their suppression. The delivery of macrophages was reduced by hydrocortisone, but enhanced by heparin and phenobarbital. The latter induced a persistent intragranulomatous granulocytosis, expressing the repair of decreased activities of dehydrogenases and especially of NADP-NADPH-oxidases. The action of these drugs was phasic, their intervention being active only during the cellular phase of granulomas; fibrillogenesis was influenced only indirectly. Extrapolation to humans of these results suggests the use of these drugs during the cellular phase of chronic pneumonitic lesions and suppression of the immune component of the inflammatory processes.
研究了在静脉注射添加人丙种球蛋白的完全弗氏佐剂诱导家兔产生的肺肉芽肿的定型发育和细胞动力学，观察了醋酸氢化可的松、利福平、肝素和苯巴比妥的影响。如同先前使用放线菌素和嘌呤霉素的研究一样，所分析的药物延缓（直至抑制，如氢化可的松）肺肉芽肿的发育，使其保持较小、未融合且无上皮样变；初级和次级免疫反应或多或少受到影响直至被抑制。氢化可的松减少巨噬细胞的输送，但肝素和苯巴比妥则增强这种输送。后者诱导肉芽肿内持续的粒细胞增多，这表现为脱氢酶尤其是NADP - NADPH - 氧化酶活性降低后的修复。这些药物的作用是阶段性的，它们仅在肉芽肿的细胞期发挥作用；纤维形成仅受到间接影响。将这些结果外推至人类提示，在慢性肺炎性病变的细胞期使用这些药物，并抑制炎症过程的免疫成分。
