Yano Yoshihiko, Yoon Seitetsu, Seo Yasushi, Ninomiya Toshiaki, Nagano Hidenobu, Nakaji Miyuki, Hayashi Yoshitake, Kasuga Masato
Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine.
Kobe J Med Sci. 2003;49(1-2):39-43.
Primary biliary cirrhosis (PBC) is a chronic progressive, autoimmune liver disease that increases the risk of hepatobiliary malignancies at a late stage. We report a 66-year-old woman with PBC combined with hepatocellular carcinoma (HCC) accompanied by hypoglycemia. Two large tumors were detected on admission and the patient died because of tumor rupture and subsequent liver failure. Histological analysis revealed well-differentiated HCC in both of the tumors. Sometimes the patient had suffered from hypoglycemic attacks of unknown origin, but serum immunoreactive insulin (IRI) was within the normal range. It was interesting that such large well-differentiated hepatocellular carcinomas were generated in PBC.
原发性胆汁性肝硬化（PBC）是一种慢性进行性自身免疫性肝病，在晚期会增加肝胆恶性肿瘤的风险。我们报告了一名66岁患有PBC合并肝细胞癌（HCC）并伴有低血糖的女性。入院时检测到两个大肿瘤，患者因肿瘤破裂及随后的肝衰竭死亡。组织学分析显示两个肿瘤均为高分化HCC。患者有时会出现不明原因的低血糖发作，但血清免疫反应性胰岛素（IRI）在正常范围内。有趣的是，在PBC中会产生如此大的高分化肝细胞癌。
