Goodman Marc T, Tung Ko Hui
Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA.
Obstet Gynecol. 2003 Jun;101(6):1221-8. doi: 10.1016/s0029-7844(03)00050-4.
To examine the hypothesis that alcohol consumption is associated with the risk of ovarian cancer by conducting a population-based, case-control study in Hawaii and Los Angeles, California.
In-person interviews were obtained from 558 women with ovarian cancer and 607 population controls regarding lifetime alcohol consumption and other factors that may be related to the development of ovarian cancer.
We found no overall association of alcohol drinking with the odds ratios (OR) for ovarian cancer. However, current alcohol drinkers, but not former drinkers, had a significantly lower OR for ovarian cancer compared with never drinkers (OR 0.69, 95% confidence interval [CI] 0.50, 0.96). Odds ratios for ovarian cancer associated with the current consumption of beer, wine, and spirits were also reduced, but were only significant for wine drinkers. Among current wine drinkers, women who drank red wine had a significantly reduced OR for ovarian cancer compared with never drinkers (OR 0.61, 95% CI 0.39, 0.94). The inverse association of current alcohol drinking with the OR for ovarian cancer was restricted to invasive tumors, especially the endometrioid cell type. The number of glasses of alcohol consumed on a weekly basis was inversely related to the OR for invasive ovarian cancer (P =.009): Current drinkers consuming 14 or more drinks per week had an OR of 0.36 (95% CI 0.19, 0.70) compared with never drinkers. A significantly increased risk of borderline serous tumors was associated with the use of spirits (OR 2.66, 95% CI 1.46, 4.85). The risk for borderline mucinous tumors was also significantly elevated for former wine drinkers.
These findings suggest that the association of alcohol consumption with the OR for ovarian cancer may vary by alcohol type, tumor invasiveness, and histology.
通过在夏威夷和加利福尼亚州洛杉矶开展一项基于人群的病例对照研究，检验饮酒与卵巢癌风险相关的假设。
对558名卵巢癌女性患者和607名人群对照进行面对面访谈，了解其终生饮酒情况以及其他可能与卵巢癌发生相关的因素。
我们发现饮酒与卵巢癌的比值比（OR）无总体关联。然而，与从不饮酒者相比，当前饮酒者而非既往饮酒者的卵巢癌OR显著更低（OR 0.69，95%置信区间[CI] 0.50，0.96）。与当前饮用啤酒、葡萄酒和烈性酒相关的卵巢癌OR也有所降低，但仅对饮用葡萄酒者有显著意义。在当前饮用葡萄酒者中，饮用红酒的女性与从不饮酒者相比，卵巢癌OR显著降低（OR 0.61，95% CI 0.39，0.94）。当前饮酒与卵巢癌OR的负相关仅限于浸润性肿瘤，尤其是子宫内膜样细胞类型。每周饮用的酒精杯数与浸润性卵巢癌的OR呈负相关（P = 0.009）：与从不饮酒者相比，每周饮用14杯或更多酒精饮料的当前饮酒者的OR为0.36（95% CI 0.19，0.70）。使用烈性酒与交界性浆液性肿瘤风险显著增加相关（OR 2.66，95% CI 1.46，4.85）。既往饮用葡萄酒者的交界性黏液性肿瘤风险也显著升高。
这些发现表明，饮酒与卵巢癌OR的关联可能因酒精类型、肿瘤浸润性和组织学而异。
