Hone P, Edwards A, Halls J, Cox R, Lloyd D
National Radiological Protection Board, Chilton, Didcot, OX11 0RQ, UK.
Br J Cancer. 2003 Jun 16;88(12):1939-41. doi: 10.1038/sj.bjc.6601010.
Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemogen by compromising DNA damage response to genotoxic agents such as ionising radiation. We examined this hypothesis using gamma-ray-induced dicentric chromosome exchange in human lymphocytes. The results from 12 h post-gamma-ray exposure to fields of 0.23, 0.47 and 0.7 mT provide no support to the hypothesis. The power of the study was sufficient to exclude an ELF enhancement of chromosomal exchange of 10-15% (2SE).
流行病学研究表明，暴露于极低频（ELF）电磁场（EMF）与儿童白血病之间存在关联。然而，这种关联的因果性质和生物学基础值得怀疑。对非整倍体细胞系的研究提出了一个假设，即ELF EMF可能通过损害对诸如电离辐射等遗传毒性剂的DNA损伤反应而作为一种协同白血病原。我们使用γ射线诱导的人淋巴细胞双着丝粒染色体交换来检验这一假设。γ射线暴露12小时后，在0.23、0.47和0.7 mT磁场下的结果不支持该假设。该研究的效能足以排除ELF使染色体交换增加10 - 15%（2倍标准误）的情况。
