Turesson Ingela, Carlsson Jörgen, Brahme Anders, Glimelius Bengt, Zackrisson Björn, Stenerlöw Bo
Unit of Oncology, Uppsala University, Uppsala, Sweden.
Acta Oncol. 2003;42(2):92-106. doi: 10.1080/02841860310004959.
In an investigation by the Swedish Cancer Society, the present status, critical issues and future aspects and potentials were described by an expert group for each of nine major areas of radiation therapy research. This article deals with biological response to radiation. Separate sections deal with molecular responses to radiation, the stem cell and clonogenic cell concepts and the importance of cell proliferation, cell and tissue responses to doses above and below 1 Gy, respectively, the potential role of intercellular signalling pathways, the so-called bystander effect and radiation biology-based therapy planning and treatment optimization.
在瑞典癌症协会开展的一项调查中，一个专家小组针对放射治疗研究的九个主要领域，分别阐述了其现状、关键问题以及未来的发展方向和潜力。本文探讨的是辐射的生物学反应。各部分分别论述了辐射的分子反应、干细胞和克隆源性细胞概念以及细胞增殖的重要性，细胞和组织对1 Gy以上及以下剂量的反应，细胞间信号通路的潜在作用、所谓的旁观者效应以及基于放射生物学的治疗计划和治疗优化。
