Lucidarme Olivier, Franchi-Abella Stephanie, Correas Jean-Michel, Bridal S Lori, Kurtisovski Erol, Berger Genevieve
Parametric Imaging Laboratory, UMR 7623 CNRS and Paris University VI, 15 rue de l'Ecole de Médecine, 75006 Paris, France.
Radiology. 2003 Aug;228(2):473-9. doi: 10.1148/radiol.2282020699. Epub 2003 Jun 11.
To investigate changes in destruction-replenishment curves (in vitro and in vivo) that result from microbubble destruction in feeding vessels that pass through the imaging plane before microbubbles enter the region of interest (ROI).
During continuous injections of an ultrasonographic contrast agent, nonlinear gray-scale images were obtained in vitro in the longitudinal plane of a renal dialysis cartridge flow phantom (flow rates of 100, 200, and 400 mL/min) and in vivo in the coronal plane of the left kidneys of two rabbits (two kidneys). Destruction-replenishment curves were obtained for the dialysis cartridge in ROIs located immediately after the entrance of the microbubbles into the image plane and further from the entrance, after microbubbles had traveled across the complete length of the imaging plane. Replenishment curves were also obtained from ROIs in the rabbit kidneys at the level of segmental arteries, distal interlobar arteries, and the cortex.
The ROIs immediately after the entrance of the microbubbles in the image plane of the dialysis cartridge and in the segmental artery of the kidney followed a typical exponential function, A(1 - e-alphat). Early portions of curves obtained in ROIs filled with microbubbles that had already passed through the image plane of the dialysis cartridge or in the renal cortex were not well described by such a function. The shape of the curve and the variations as a function of flow rate can be explained by means of a mathematical model based on indicator-dilution theory.
When the feeding vessels of an ROI travel across the ultrasound field before they reach the measurement region, the typical shape of the replenishment curve is modified (reduced velocity parameter and plateau).
研究在微泡进入感兴趣区域（ROI）之前穿过成像平面的供血血管中微泡破坏所导致的破坏-再充盈曲线（体外和体内）的变化。
在连续注射超声造影剂期间，在体外肾透析盒血流模型的纵切面（流速分别为100、200和400 mL/min）以及在两只兔子左肾的冠状面（两个肾脏）体内获取非线性灰度图像。在微泡进入图像平面后紧接着的ROI以及微泡穿过成像平面全长后离入口更远的ROI中，获取透析盒的破坏-再充盈曲线。还从兔子肾脏的节段动脉、叶间动脉远端和皮质水平的ROI中获取再充盈曲线。
在透析盒图像平面中微泡进入后紧接着的ROI以及肾脏节段动脉中的ROI遵循典型的指数函数A(1 - e-αt)。在已穿过透析盒图像平面的微泡所填充的ROI或肾皮质中获得的曲线早期部分，该函数无法很好地描述。曲线的形状以及作为流速函数的变化可以通过基于指示剂稀释理论的数学模型来解释。
当ROI的供血血管在到达测量区域之前穿过超声场时，再充盈曲线的典型形状会被改变（速度参数降低和平坦化）。
