Rogovskaya S I, Zhdanov A V, Loginova N S, Faizullin L Z, Prilepskaya V N, Van'ko L V, Sukhikh G T
Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2002 Nov;134(5):463-6. doi: 10.1023/a:1022694431471.
The interferon system was studied in women with genital papillomavirus infection. In most patients the interferon system was activated, while the ability of lymphocytes to respond to inductors decreased. Laserotherapy and immunomodulatory therapy with larifan, ridostin, and viferon for 1 month normalized blood interferon concentration (39.4% patients) and interferon-gamma production by lymphocytes in response to inductors (87.9% patients). After laser monotherapy these parameters returned to normal only in 13.2 and 7.6% patients, respectively. Correlation and regression analyses showed that changes in the interferon system were synchronized after immunomodulatory therapy. These data indicate that immunomodulatory therapy produces a complex effect on the interferon system. Measurements of blood interferon level can be used to predict the effect of further treatment with interferon-gamma inductors.
对患有生殖器乳头瘤病毒感染的女性的干扰素系统进行了研究。在大多数患者中，干扰素系统被激活，而淋巴细胞对诱导剂的反应能力下降。使用拉立泛、利多司汀和维福隆进行激光疗法和免疫调节治疗1个月后，血液干扰素浓度恢复正常（39.4%的患者），淋巴细胞对诱导剂产生的γ干扰素也恢复正常（87.9%的患者）。单纯激光治疗后，这些参数仅在13.2%和7.6%的患者中恢复正常。相关性和回归分析表明，免疫调节治疗后干扰素系统的变化是同步的。这些数据表明，免疫调节治疗对干扰素系统产生复杂的影响。血液干扰素水平的测量可用于预测进一步使用γ干扰素诱导剂治疗的效果。
