Thiery J P, Mazabraud A, Voisin M C, Lacroix G, Baviera E
Rev Chir Orthop Reparatrice Appar Mot. 1975 Jul-Aug;61(5):377-86.
A cyto-enzymologic study of giant cells tumor revealed a high acid phosphatase activity in multi-nuclear cells (as in osteoclasts) and a very low alcaline phosphatase and peroxydase activity. Acid phosphatase was located in lysosom which were concentrated in definite cytoplasmic areas. The blood rate of this enzyme should be raised if it were excreted by the cells. Therefore a study of acid phosphatase blood rate could reinforce a diagnosis based on X-rays and a raising rate after surgery could help for early detection of recurrences.
骨巨细胞瘤的细胞酶学研究显示，多核细胞（如破骨细胞）中酸性磷酸酶活性较高，而碱性磷酸酶和过氧化物酶活性极低。酸性磷酸酶位于溶酶体中，溶酶体集中在特定的细胞质区域。如果该酶由细胞分泌，其血中水平应会升高。因此，酸性磷酸酶血中水平的研究可加强基于X线的诊断，术后该水平的升高有助于早期发现复发。
