Nakagomi O, Kaga E, Nakagomi T
Department of Laboratory Medicine, Akita University School of Medicine, Japan.
Arch Virol. 1992;127(1-4):365-71. doi: 10.1007/BF01309599.
Human rotavirus strain K8, which possesses unique VP4 neutralization epitopes, was examined by RNA-RNA hybridization to determine its genogroup. While it possessed four gene segments that formed hybrids with strain Wa (a prototype of the Wa genogroup), strain K8 possessed seven gene segments, including gene segment 4, that formed hybrids with strain AU-1 (a prototype of the AU-1 genogroup) which has been shown to share a unique gene 4 allele with feline rotaviruses. These results suggest that strain K8 is an intergenogroup reassortant formed in nature between a member of the Wa genogroup and a member of the AU-1 genogroup.
人类轮状病毒K8株具有独特的VP4中和表位，通过RNA - RNA杂交对其进行检测以确定其基因群组。虽然它有四个基因片段能与Wa株（Wa基因群组的原型）形成杂交体，但K8株有七个基因片段，包括基因片段4，能与AU - 1株（AU - 1基因群组的原型）形成杂交体，而AU - 1株已被证明与猫轮状病毒共享一个独特的基因4等位基因。这些结果表明，K8株是在自然界中由Wa基因群组的一个成员和AU - 1基因群组的一个成员之间形成的基因群组间重配体。
