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有机阴离子转运是溶质载体家族17/Ⅰ型磷酸转运体家族的主要功能。

Organic anion transport is the primary function of the SLC17/type I phosphate transporter family.

作者信息

Reimer Richard J, Edwards Robert H

机构信息

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA 94305, Stanford, USA,

出版信息

Pflugers Arch. 2004 Feb;447(5):629-35. doi: 10.1007/s00424-003-1087-y. Epub 2003 Jun 17.

DOI:10.1007/s00424-003-1087-y
PMID:12811560
Abstract

Recently, molecular studies have determined that the SLC17/type I phosphate transporters, a family of proteins initially characterized as phosphate carriers, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitter glutamate to the degradation and metabolism of glycoproteins.

摘要

最近,分子研究已确定,溶质载体家族17/Ⅰ型磷酸转运体(最初被确定为磷酸载体的一类蛋白质)介导有机阴离子的转运。虽然它们在磷酸盐转运中的作用仍不确定,但现在很清楚,由这类蛋白质促进的有机阴离子转运参与了从神经递质谷氨酸的囊泡储存到糖蛋白降解和代谢等多种过程。

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Secretory granule-mediated co-secretion of L-glutamate and glucagon triggers glutamatergic signal transmission in islets of Langerhans.分泌颗粒介导的L-谷氨酸和胰高血糖素共分泌触发胰岛中的谷氨酸能信号传递。
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The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection.氨基酸在神经传递中的作用及荧光检测工具。
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