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本文引用的文献

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Functional and anatomical identification of a vesicular transporter mediating neuronal ATP release.介导神经元 ATP 释放的囊泡转运体的功能和解剖学鉴定。
Cereb Cortex. 2012 May;22(5):1203-14. doi: 10.1093/cercor/bhr203. Epub 2011 Aug 1.
2
Use of the hydantoin isostere to produce inhibitors showing selectivity toward the vesicular glutamate transporter versus the obligate exchange transporter system x(c)(-).利用海因环系来制备抑制剂,使其对囊泡谷氨酸转运体具有选择性,而不是对必需的交换转运体系统 x(c)(-)。
Bioorg Med Chem Lett. 2011 Jul 15;21(14):4358-62. doi: 10.1016/j.bmcl.2011.05.018. Epub 2011 May 14.
3
Regulation of purinergic signaling in biliary epithelial cells by exocytosis of SLC17A9-dependent ATP-enriched vesicles.SLC17A9 依赖性富含 ATP 囊泡的胞吐作用调节胆管上皮细胞的嘌呤能信号转导。
J Biol Chem. 2011 Jul 15;286(28):25363-76. doi: 10.1074/jbc.M111.232868. Epub 2011 May 25.
4
Sodium-dependent phosphate cotransporters: lessons from gene knockout and mutation studies.钠依赖性磷酸盐协同转运蛋白:基因敲除和突变研究的启示。
J Pharm Sci. 2011 Sep;100(9):3719-30. doi: 10.1002/jps.22614. Epub 2011 May 12.
5
From glutamate co-release to vesicular synergy: vesicular glutamate transporters.从谷氨酸共释放到囊泡协同作用:囊泡谷氨酸转运体。
Nat Rev Neurosci. 2011 Apr;12(4):204-16. doi: 10.1038/nrn2969.
6
Metabolic control of vesicular glutamate transport and release.囊泡谷氨酸转运和释放的代谢控制。
Neuron. 2010 Oct 6;68(1):99-112. doi: 10.1016/j.neuron.2010.09.002.
7
Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.人源磷酸钠转运蛋白 4(hNPT4/SLC17A3)作为药物和尿酸的共同肾脏分泌途径。
J Biol Chem. 2010 Nov 5;285(45):35123-32. doi: 10.1074/jbc.M110.121301. Epub 2010 Sep 1.
8
Rose Bengal analogs and vesicular glutamate transporters (VGLUTs).玫瑰孟加拉类似物和囊泡谷氨酸转运体(VGLUTs)。
Bioorg Med Chem. 2010 Sep 15;18(18):6922-33. doi: 10.1016/j.bmc.2010.06.069. Epub 2010 Jun 25.
9
Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter.1 型钠离子依赖的磷酸盐转运蛋白(SLC17A1 蛋白)是一种氯离子依赖的尿酸盐外排体。
J Biol Chem. 2010 Aug 20;285(34):26107-13. doi: 10.1074/jbc.M110.122721. Epub 2010 Jun 21.
10
Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes.SLC17 转运蛋白唾液酸酶的结构-功能研究鉴定出关键残基和底物诱导的构象变化。
J Biol Chem. 2010 Jun 18;285(25):19316-23. doi: 10.1074/jbc.M110.130716. Epub 2010 Apr 27.

SLC17:一个具有多种功能的有机阴离子转运体家族。

SLC17: a functionally diverse family of organic anion transporters.

机构信息

Neurogenetics Division Department of Neurology and Neurological Sciences, Stanford University School of Medicine, P211 MSLS, 1201 Welch Road, Stanford, CA 94305, USA.

出版信息

Mol Aspects Med. 2013 Apr-Jun;34(2-3):350-9. doi: 10.1016/j.mam.2012.05.004.

DOI:10.1016/j.mam.2012.05.004
PMID:23506876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3927456/
Abstract

Molecular studies have determined that the SLC17 transporters, a family of nine proteins initially implicated in phosphate transport, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitters, to urate metabolism, to the degradation and metabolism of glycoproteins.

摘要

分子研究已经确定,SLC17 转运蛋白家族最初涉及磷酸盐转运,介导有机阴离子的转运。虽然它们在磷酸盐转运中的作用仍然不确定,但现在很清楚,由该蛋白家族促进的有机阴离子转运参与了从神经递质囊泡储存到尿酸代谢,再到糖蛋白降解和代谢的各种过程。