Neurogenetics Division Department of Neurology and Neurological Sciences, Stanford University School of Medicine, P211 MSLS, 1201 Welch Road, Stanford, CA 94305, USA.
Mol Aspects Med. 2013 Apr-Jun;34(2-3):350-9. doi: 10.1016/j.mam.2012.05.004.
Molecular studies have determined that the SLC17 transporters, a family of nine proteins initially implicated in phosphate transport, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitters, to urate metabolism, to the degradation and metabolism of glycoproteins.
分子研究已经确定,SLC17 转运蛋白家族最初涉及磷酸盐转运,介导有机阴离子的转运。虽然它们在磷酸盐转运中的作用仍然不确定,但现在很清楚,由该蛋白家族促进的有机阴离子转运参与了从神经递质囊泡储存到尿酸代谢,再到糖蛋白降解和代谢的各种过程。