Poni Esteban S, Liwnicz Boleslaw H, Ying-Ying Yue, North Mary
Instituto Venezolano de los Seguros Sociales, Hospital General, Dr. Pastor Oropeza, Barquisimeto, Estado Lara, Venezuela.
Invest Clin. 2003 Jun;44(2):137-45.
The goal of this study was to evaluate the participation of small (diameter between 26 microns and 90 microns) and terminal (diameter between 10 microns and 25 microns) arterioles in the status lacunaris of the basal ganglia and to classify tortuous vascular profiles based on morphometry. Paraffin sections, 40 microns thick, of the basal ganglia from autopsied patients over the age of 45, were stained with PAS. A three-dimensional microscope, R400 (edge) was used to evaluate the structure of the blood vessels. Six patterns of the tortuous profiles were identified: simple kink, loop, knot, tangle, coil, and wave, and well as their combinations. Tortuous arterioles in the basal ganglia were present both in control group and status lacunaris cases. However, statistical Student's t-test analysis revealed a significant increment in the number of microfields containing tortuous terminal arterioles in the status lacunaris group (mean 7.50 +/- 4.62) versus the control group (mean 2.92 +/- 1.38) (p = 0.001). A risk for status lacunaris was associated with the increased frequency of tortuous terminal arterioles (Odd ratio = 1.94, 95%-Confidence Interval = 1.17-3.22) (p = 0.008) but not small arterioles (Odd ratio = 1.64, 95%-Confidence Interval = 0.62-4.38) (p = 0.39). Our findings suggest than an increased number of tortuous terminal arterioles is associated with status lacunaris. Six characteristic patterns of the tortuous profiles as well as their combinations were identified.
本研究的目的是评估小动脉（直径在26微米至90微米之间）和终末动脉（直径在10微米至25微米之间）在基底节腔隙状态中的参与情况，并基于形态计量学对迂曲的血管形态进行分类。对45岁以上尸检患者的基底节进行40微米厚的石蜡切片，用PAS染色。使用R400（edge）三维显微镜评估血管结构。识别出六种迂曲形态模式：简单扭结、环、结、缠结、螺旋和波浪，以及它们的组合。基底节中的迂曲小动脉在对照组和腔隙状态病例中均存在。然而，统计学学生t检验分析显示，腔隙状态组（平均7.50±4.62）中含有迂曲终末小动脉的微视野数量与对照组（平均2.92±1.38）相比有显著增加（p = 0.001）。腔隙状态的风险与迂曲终末小动脉频率增加相关（优势比=1.94，95%置信区间=1.17 - 3.22）（p = 0.008），但与小动脉无关（优势比=1.64，95%置信区间=0.62 - 4.38）（p = 0.39）。我们的研究结果表明，迂曲终末小动脉数量增加与腔隙状态相关。识别出六种迂曲形态的特征模式及其组合。
