Spangler K M, Challa V R, Moody D M, Bell M A
Department of Radiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1088.
J Neuropathol Exp Neurol. 1994 Jan;53(1):22-6. doi: 10.1097/00005072-199401000-00003.
Previous studies have shown tortuous arteries and arterioles in the brains of older people, but the effects of age and other factors have not been studied. To examine the effects of hypertension, age, race and sex on white matter (WM) arteriolar tortuosity (AT), we performed high-resolution microradiography and morphometry of human brains taken at autopsy from 44 subjects of various ages (range 30-96 years; 31 hypertensives/13 normotensives). About 70% of tortuosities in the WM were found at the gray-white interfaces of the insular region and adjacent subcortical-WM of the inferior frontal and superior temporal gyri. Six morphologic types of tortuous profiles were identified. The number of tortuous profiles increased with age, but not significantly. Hypertension, sex and race had no effect on tortuosity. Our findings also suggest that 1) WM AT is found mostly at the interfaces between gray matter and WM and, therefore, 2) the physical properties of the WM somehow predispose to the development of AT; 3) AT is not associated with tortuosity in the veins; and 4) the location of complex arteriolar coils supports a recent claim that they can be mistaken for the Charcôt-Bouchard microaneurysms if injection of contrast media and low-magnification radiography of the brain slices are employed for that purpose.
以往的研究显示，老年人脑内存在迂曲的动脉和小动脉，但年龄及其他因素的影响尚未得到研究。为了研究高血压、年龄、种族和性别对白质（WM）小动脉迂曲度（AT）的影响，我们对44名不同年龄（范围30 - 96岁；31名高血压患者/13名血压正常者）尸检获得的人脑进行了高分辨率微放射成像和形态测量。约70%的WM迂曲出现在岛叶区域的灰白质界面以及额下回和颞上回相邻的皮质下WM处。识别出六种迂曲形态类型。迂曲形态的数量随年龄增加，但增加不显著。高血压、性别和种族对迂曲度无影响。我们的研究结果还表明：1）WM AT大多出现在灰质与WM的界面处，因此，2）WM的物理特性在某种程度上易导致AT的形成；3）AT与静脉迂曲无关；4）复杂小动脉盘绕的位置支持了最近的一种说法，即如果为此目的采用脑切片造影剂注射和低倍放射成像，它们可能会被误认为是Charcôt - Bouchard微动脉瘤。
