Prodi G, Rocchi P, Grilli S
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Nov 25;84(3):281-9. doi: 10.1007/BF00312249.
Urethan, in a single dose of 1 mg/g body weight, exerts a strong inhibitory effect on DNA synthesis in lymphoid organs and bone marrow of rat. The inhibition observed in spleen and thymus is longer lasting than that exerted on bone marrow or regenerating liver, demonstrating a marked sensitivity of lymphoid cells to the drug. This effect can explain the rapid reduction of weight and cell number in thymus and spleen under urethan treatment, in absence of any lymphocytolytic action. The different effect of urethan on the different subpopulations of lymphoid cells therefore appears to be due to their kinetics rather than to a specific sensitivity of some of them.
乌拉坦，以1毫克/克体重的单次剂量，对大鼠的淋巴器官和骨髓中的DNA合成产生强烈抑制作用。在脾脏和胸腺中观察到的抑制作用比在骨髓或再生肝脏中持续的时间更长，表明淋巴细胞对该药物具有明显的敏感性。这种作用可以解释在乌拉坦治疗下胸腺和脾脏重量和细胞数量的迅速减少，而不存在任何淋巴细胞溶解作用。因此，乌拉坦对不同淋巴细胞亚群的不同作用似乎是由于它们的动力学，而不是由于其中一些细胞的特定敏感性。
