Carmona Doris, Sáez Jairo, Granados Hillmer, Pérez Edwin, Blair Silvia, Angulo Alberto, Figadere Bruno
Institute of Chemistry, Universidad de Antioquia, P.O. Box 1226, Medellín-Colombia.
Nat Prod Res. 2003 Aug;17(4):275-80. doi: 10.1080/1057563031000065062.
Dichloromethane extracts of both the roots and the leaves of Raimondia cf. monoica showed in vitro antiplasmodial and leishmanicidal activities against Plasmodium falciparum and Leishmania panamensis, respectively. Three 6-substituted 5,6-dihydro-2H-pyran-2-ones were isolated. (1) and (2) were identified as (6S)-(5'-oxohepten-1'E,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one (1) and (6R)-(5'-oxohepten-1'Z,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one (2), respectively. (-)-Arentilactone (3) was also isolated. The structure of the new compound (1) was determined by spectroscopic methods; additional spectroscopic data for (2) are reported for the first time.
雷蒙德草（Raimondia cf. monoica）根和叶的二氯甲烷提取物分别对恶性疟原虫和巴拿马利什曼原虫显示出体外抗疟和抗利什曼原虫活性。分离出了三种6-取代的5,6-二氢-2H-吡喃-2-酮。（1）和（2）分别被鉴定为（6S）-（5'-氧代庚-1'E,3'E-二烯基）-5,6-二氢-2H-吡喃-2-酮（1）和（6R）-（5'-氧代庚-1'Z,3'E-二烯基）-5,6-二氢-2H-吡喃-2-酮（2）。还分离出了（-）-阿伦替内酯（3）。新化合物（1）的结构通过光谱方法确定；首次报道了（2）的额外光谱数据。
