膳食蘑菇（平菇）可改善高胆固醇血症大鼠的致动脉粥样硬化脂质。

Dietary mushroom (Pleurotus ostreatus) ameliorates atherogenic lipid in hypercholesterolaemic rats.

Hossain Shahdat, Hashimoto Michio, Choudhury Emran Kabir, Alam Nuhu, Hussain Shahjalal, Hasan Moynul, Choudhury Shahabuddin Kabir, Mahmud Ishtiaq

Department of Physiology, Shimane Medical University, Shimane, Japan.

Clin Exp Pharmacol Physiol. 2003 Jul;30(7):470-5. doi: 10.1046/j.1440-1681.2003.03857.x.

Abstract

The effects of edible oyster mushroom Pleurotus ostreatus on plasma and liver lipid profiles and on the plasma total anti-oxidant status were estimated in hyper- and normocholesterolaemic Long Evans rats. 2. The feeding of 5% powder of the fruiting bodies of P. ostreatus mushrooms to hypercholesterolaemic rats reduced their plasma total cholesterol by approximately 28%, low-density lipoprotein-cholesterol by approximately 55%, triglyceride by approximately 34%, non-esterified fatty acid by approximately 30% and total liver cholesterol levels by > 34%, with a concurrent increase in plasma high-density lipoprotein-cholesterol concentration of > 21%. However, these effects were not observed in mushroom-fed normocholesterolaemic rats. 3. Mushroom feeding significantly increased plasma fatty acid unsaturation in both normo- and hypercholesterolaemic rats. 4. Plasma total anti-oxidant status, as estimated by the oxidation of 2,2'-azino-bis-[3-ethylbenz-thiazoline-6-sulphonic-acid], was significantly decreased in mushroom-fed hypercholesterolaemic rats, concomitant with a decrease in plasma total cholesterol. 5. The present study suggests that 5% P. ostreatus supplementation provides health benefits, at least partially, by acting on the atherogenic lipid profile in the hypercholesterolaemic condition.

摘要

在高胆固醇血症和正常胆固醇血症的长 Evans 大鼠中，评估了食用平菇对血浆和肝脏脂质谱以及血浆总抗氧化状态的影响。2. 给高胆固醇血症大鼠喂食 5% 的平菇子实体粉末，可使其血浆总胆固醇降低约 28%，低密度脂蛋白胆固醇降低约 55%，甘油三酯降低约 34%，非酯化脂肪酸降低约 30%，肝脏总胆固醇水平降低超过 34%，同时血浆高密度脂蛋白胆固醇浓度升高超过 21%。然而，在喂食平菇的正常胆固醇血症大鼠中未观察到这些效果。3. 在正常胆固醇血症和高胆固醇血症大鼠中，喂食平菇均显著增加了血浆脂肪酸不饱和度。4. 通过 2,2'- 联氮 - 双 -[3 - 乙基苯并噻唑啉 - 6 - 磺酸] 氧化评估的血浆总抗氧化状态，在喂食平菇的高胆固醇血症大鼠中显著降低，同时血浆总胆固醇也降低。5. 本研究表明，补充 5% 的平菇至少部分通过作用于高胆固醇血症状态下的致动脉粥样硬化脂质谱而提供健康益处。