Hung Ling-Hong, Samudrala Ram
Computational Genomics Group, Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Nucleic Acids Res. 2003 Jul 1;31(13):3296-9. doi: 10.1093/nar/gkg541.
Information about the secondary and tertiary structure of a protein sequence can greatly assist biologists in the generation and testing of hypotheses, as well as design of experiments. The PROTINFO server enables users to submit a protein sequence and request a prediction of the three-dimensional (tertiary) structure based on comparative modeling, fold generation and de novo methods developed by the authors. In addition, users can submit NMR chemical shift data and request protein secondary structure assignment that is based on using neural networks to combine the chemical shifts with secondary structure predictions. The server is available at http://protinfo.compbio.washington.edu.
蛋白质序列二级和三级结构的信息能够极大地帮助生物学家提出和检验假设，以及设计实验。PROTINFO服务器允许用户提交蛋白质序列，并基于作者开发的比较建模、折叠生成和从头预测方法来请求对三维（三级）结构进行预测。此外，用户可以提交核磁共振化学位移数据，并请求基于使用神经网络将化学位移与二级结构预测相结合的蛋白质二级结构归属。该服务器可通过http://protinfo.compbio.washington.edu访问。
