在爱泼斯坦-巴尔病毒染色质中，EBNA2启动子特异性募集时组蛋白H3和H4的差异超乙酰化
Differential hyperacetylation of histones H3 and H4 upon promoter-specific recruitment of EBNA2 in Epstein-Barr virus chromatin.
作者信息
Alazard Nathalie, Gruffat Henri, Hiriart Edwige, Sergeant Alain, Manet Evelyne
机构信息
Unité de Virologie Humaine, U412 INSERM, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
出版信息
J Virol. 2003 Jul;77(14):8166-72. doi: 10.1128/jvi.77.14.8166-8172.2003.
Abstract
Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transcriptional activator involved in the immortalization of B lymphocytes by the virus. EBNA2 is targeted to the promoters of its responsive genes, via interaction with cellular DNA-binding proteins. Using chromatin immunoprecipitation assays, we show for the first time the conditional recruitment of EBNA2 on two specific viral promoters in vivo and demonstrate a correlation between this recruitment and a local change in the acetylation of histones H3 and H4, which is promoter dependent.
摘要
爱泼斯坦-巴尔病毒核抗原2（EBNA2）是一种转录激活因子，参与该病毒对B淋巴细胞的永生化过程。EBNA2通过与细胞DNA结合蛋白相互作用，靶向其反应基因的启动子。利用染色质免疫沉淀分析，我们首次在体内证明了EBNA2在两个特定病毒启动子上的条件性募集，并证明这种募集与组蛋白H3和H4乙酰化的局部变化之间存在相关性，且这种变化依赖于启动子。
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