巴西大西洋雨林植物物种提取物的杀锥虫活性。
Trypanocidal activity of extracts from Brazilian Atlantic Rain Forest plant species.
作者信息
Pizzolatti M G, Koga A H, Grisard E C, Steindel M
机构信息
Department de Química, Laboratório de Química de Produtos Naturais, Florianópolis, SC, Brazil.
出版信息
Phytomedicine. 2003;10(5):422-6. doi: 10.1078/0944-7113-00252.
The trypanocidal activity of crude hydro alcoholic extracts and several fractions of 13 plants from Brazilian Atlantic Rain Forest were tested in vitro against epimastigote and trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas disease. Crude ethanol extracts with promising in vitro activity (DL50 between 5-10 microg/ml) against epimastigotes were fractionated by solvent partition and further tested against bloodstream form of the parasite. Activity against bloodstream parasites was observed in both dichloromethane and hexane fractions of Polygala sabulosa and P. paniculata.
对来自巴西大西洋雨林的13种植物的粗水醇提取物及其几个馏分的杀锥虫活性进行了体外测试，以检测其对恰加斯病的病原体克氏锥虫的前鞭毛体和锥鞭毛体形式的活性。对前鞭毛体具有体外活性（半数致死剂量在5-10微克/毫升之间）的粗乙醇提取物通过溶剂分配进行分馏，并进一步针对该寄生虫的血流形式进行测试。在远志和圆锥远志的二氯甲烷和己烷馏分中均观察到了对血流寄生虫的活性。
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